We are seeking motivated, innovative, skilled and enthusiastic human geneticists to join our expanding team within the Human Genetics (HG) department. Candidates should be keen to apply state of the art genetic knowledge to drive decision making across the GSK pipeline, working in partnership with scientists in HG and in the broader Research organization, to generate biological insights that will translate into innovative new medicines for patients.
At the core of GSK’s R&D approach is the identification of new medicines by leveraging the vast amounts of human genetic and genomic data now being generated and applying cutting edge technologies in functional genomics and machine learning.
Within the Human Genetics team, we leverage major scientific and technological advances, including investment in biobanks linked to large-scale human health databases, cutting-edge informatics platforms and integration of biological pathway and functional genomics data to identify novel targets. We continue to evaluate these targets throughout their life in the pipeline, using genetics and genomics to identify the patients that are most likely to benefit and biomarkers to select these patients and assess efficacy.
Successful candidates will work in a multidisciplinary, collaborative and scientifically driven environment, interacting with GSK scientists and external collaborators to advance GSK drug discovery and clinical development. This field-leading research addresses important drug discovery and development challenges, directly impacts GSK’s R&D pipeline, and leads to publication in top scientific journals.
Key Responsibilities include, but are not limited to:
Identify and implement opportunities for genetics-based science to improve GSK target quality and use human genetic evidence to drive decisions on target selection, validation and patient stratification across a range of disease areas.
Be responsible for detailed genetic assessments to inform GSK project progression decisions and to identify learnings and opportunities to impact broader target discovery and validation strategies.
Lead and participate in project teams with GSK scientists and external collaborators
Be responsible for effective communication of genetic findings, with expert interpretation, to relevant stakeholders and project teams.
Find creative solutions and work with agility to address challenging scientific questions.
Contribute to the developing science of drug target identification and validation, providing scientific expertise within Human Genetics and across the Research organization.
Multiple Locations: Collegeville, Pennsylvania; Cambridge, Massachusetts; Stevenage, United Kingdom;
We are looking for professionals with these required skills to achieve our goals:
PhD or equivalent work experience in human genetics, statistical genetics, genetic epidemiology or related field.
Demonstrated project leadership examples and experience leading teams to find creative and innovate ways to address scientific questions.
Experience in analysis and interpretation of population based genetic studies including genome wide and phenome wide association studies, including evidence of working across disciplines to advance understanding
Strong verbal and written communication skills to communicate complex concepts in the genomics and genetics area to influence diverse audiences.
Demonstrated experience leading and working within collaborative, multidisciplinary teams.
If you have the following characteristics, it would be a plus:
Data science skills to collect, integrate, mine and analyze complex biological data and translate them into testable hypotheses.
Knowledge of functional genomics, oncology, immunology or epidemiology
Experience leveraging external collaborations to augment internal capabilities.
Integration of additional molecular data, eg from gene expression profiling, metabolomics, or proteomics, into genetic analyses.
Knowledge of the drug discovery and development process.
GSK aims to improve the number of successful late stage clinical trials for innovative medicines, by both identifying and advancing drug targets that have strong evidence of a causal role in disease biology. The Human Genetics team leverages major scientific and technological advances, including investment in biobanks linked to large-scale human health databases, cutting-edge informatics platforms, breakthrough understanding of biological pathways, functional genomics capabilities built upon rapid progress in gene editing, and leading industry-academia partnerships, in order to identify the best targets and to continue evaluation of targets through their life in the pipeline.
We are seeking motivated, innovative, skilled and experienced Individuals to join our expanding team within the Human Genetics department. Candidates should be keen to drive and apply state of the art analysis methods to inform decision making across the GSK pipeline, integrating diverse and complex data types to translate genetic signals into innovative new medicines for patients with unmet medical need.